TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation

TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation

<p>Abstract</p> <p>Background</p> <p>Chronic neuroinflammation is a hallmark of several neurological disorders associated with cognitive loss. Activated microglia and secreted factors such as tumor necrosis factor (TNF)-α are key mediators of neuroinflammation and may c...

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Bibliographic Details
Main Authors: Belarbi Karim, Jopson Timothy, Tweedie David, Arellano Carla, Luo Weiming, Greig Nigel H, Rosi Susanna
Format: Article
Language:English
Published: BMC 2012-01-01
Series:Journal of Neuroinflammation
Subjects:
Arc
Hippocampus
Immediate-early gene
Inflammation
Learning and memory
Tumor necrosis factor-α
Online Access:http://www.jneuroinflammation.com/content/9/1/23

Internet

http://www.jneuroinflammation.com/content/9/1/23

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