Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain

Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain

Abstract Background In patients with HIV/AIDS receiving antiretroviral therapy (ART), HIV-1 persistence in brain tissue is a vital and unanswered question. HIV-1 infects and replicates in resident microglia and trafficking macrophages within the brain although the impact of individual ART drugs on v...

Full description

Bibliographic Details
Main Authors: Eugene L. Asahchop, Oussama Meziane, Manmeet K. Mamik, Wing F. Chan, William G. Branton, Lothar Resch, M. John Gill, Elie Haddad, Jean V. Guimond, Mark A. Wainberg, Glen B. Baker, Eric A. Cohen, Christopher Power
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Retrovirology
Subjects:
HIV-1
Nervous system
Antiretroviral therapy
BLT mouse
Macrophages
Microglia
Online Access:http://link.springer.com/article/10.1186/s12977-017-0370-5

Internet

http://link.springer.com/article/10.1186/s12977-017-0370-5

Similar Items