Prevention of chemotherapy-induced premature ovarian insufficiency in mice by scaffold-based local delivery of human embryonic stem cell-derived mesenchymal progenitor cells

Prevention of chemotherapy-induced premature ovarian insufficiency in mice by scaffold-based local delivery of human embryonic stem cell-derived mesenchymal progenitor cells

Abstract Background Premature ovarian insufficiency (POI) is one of the most serious side effects of chemotherapy in young cancer survivors. It may not only reduce fecundity but also affect lifelong health. There is no standard therapy for preserving ovarian health after chemotherapy. Recently, admi...

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Bibliographic Details
Main Authors: Eun-Young Shin, Da-Seul Kim, Min Ji Lee, Ah Reum Lee, Sung Han Shim, Seung Woon Baek, Dong Keun Han, Dong Ryul Lee
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Stem Cell Research & Therapy
Subjects:
Chemotherapy-induced premature ovarian insufficiency
Embryonic stem cell-derived mesenchymal progenitor cells
Bioinspired scaffold
Cell therapy
Oncofertility
Local delivery
Online Access:https://doi.org/10.1186/s13287-021-02479-3

Internet

https://doi.org/10.1186/s13287-021-02479-3

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