Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway

Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway

The recurrence of osteosarcoma (OS) after reconstruction using Ti6Al4V prostheses remains a major problem in the surgical treatment of OS. Modification of the surfaces of Ti6Al4V prostheses with antitumor functions is an important strategy for improving therapeutic outcomes. Magnesium (Mg) coating h...

Full description

Bibliographic Details
Main Authors: X. Wei, Z. Tang, H. Wu, X. Zuo, H. Dong, L. Tan, W. Wang, Y. Liu, Z. Wu, L. Shi, N. Wang, X. Li, X. Xiao, Z. Guo
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Materials Today Bio
Subjects:
Magnesium
Coating
Antitumour
Autophagy
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006421000557

Internet

http://www.sciencedirect.com/science/article/pii/S2590006421000557

Similar Items