Harnessing immunotherapy for brain metastases: insights into tumor–brain microenvironment interactions and emerging treatment modalities

Harnessing immunotherapy for brain metastases: insights into tumor–brain microenvironment interactions and emerging treatment modalities

Abstract Brain metastases signify a deleterious milestone in the progression of several advanced cancers, predominantly originating from lung, breast and melanoma malignancies, with a median survival timeframe nearing six months. Existing therapeutic regimens yield suboptimal outcomes; however, burg...

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Bibliographic Details
Main Authors: Dairan Zhou, Zhenyu Gong, Dejun Wu, Chao Ma, Lijun Hou, Xiaomin Niu, Tao Xu
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Hematology & Oncology
Subjects:
Brain metastases
Tumor microenvironment
Immunotherapy
Immune checkpoint inhibitors
CAR-T cells
Glial cells
Online Access:https://doi.org/10.1186/s13045-023-01518-1

Internet

https://doi.org/10.1186/s13045-023-01518-1

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