Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistance

Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistance

Abstract Colorectal cancer (CRC) is a devastating disease, ranking as the second leading cause of cancer-related deaths worldwide. Immune checkpoint inhibitors (ICIs) have emerged as promising treatments; however, their efficacy is largely restricted to a subgroup of microsatellite instable (MSI) CR...

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Bibliographic Details
Main Authors: A. Esposito, A. Agostini, G. Quero, G. Piro, L. Priori, A. Caggiano, G. Scaglione, A. Battaglia, M. A. Calegari, L. Salvatore, M. Bensi, M. G. Maratta, A. Ceccarelli, G. Trovato, G. Genovese, E. Gurreri, S. Ascrizzi, M. Martini, C. Fiorillo, A. Fattorossi, F. De Sanctis, S. Ugel, V. Corbo, S. Alfieri, G. Tortora, C. Carbone
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07266-5

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https://doi.org/10.1038/s41419-024-07266-5

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