The Characteristics and Regulatory Mechanisms of Superoxide Generation from eNOS Reductase Domain.

In addition to superoxide (O2.-) generation from nitric oxide synthase (NOS) oxygenase domain, a new O2.- generation site has been identified in the reductase domain of inducible NOS (iNOS) and neuronal NOS (nNOS). Cysteine S-glutathionylation in eNOS reductase domain also induces O2.- generation fr...

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Bibliographic Details
Main Authors: Hu Peng, Yugang Zhuang, Yuanzhuo Chen, Alicia N Rizzo, Weiguo Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4605588?pdf=render