Proteolytic α-Synuclein Cleavage in Health and Disease

Proteolytic α-Synuclein Cleavage in Health and Disease

In Parkinson’s disease, aggregates of α-synuclein within Lewy bodies and Lewy neurites represent neuropathological hallmarks. However, the cellular and molecular mechanisms triggering oligomeric and fibrillary α-synuclein aggregation are not fully understood. Recent evidence indicates that oxidative...

Full description

Bibliographic Details
Main Authors: Alexandra Bluhm, Sarah Schrempel, Stephan von Hörsten, Anja Schulze, Steffen Roßner
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
α-synuclein
post-translational modification
proteolysis
Parkinson’s disease
dementia with Lewy bodies
substantia nigra
Online Access:https://www.mdpi.com/1422-0067/22/11/5450

Internet

https://www.mdpi.com/1422-0067/22/11/5450

Similar Items