Metformin attenuates LPS-induced neuronal injury and cognitive impairments by blocking NF-κB pathway

Metformin attenuates LPS-induced neuronal injury and cognitive impairments by blocking NF-κB pathway

Abstract Background Neuroinflammatory response is considered to be a high-risk factor for cognitive impairments in the brain. Lipopolysaccharides (LPS) is an endotoxin that induces acute inflammatory responses in injected bodies. However, the molecular mechanisms underlying LPS-associated cognitive...

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Bibliographic Details
Main Authors: Chenliang Zhou, Bo Peng, Zhenghui Qin, Wei Zhu, Cuiping Guo
Format: Article
Language:English
Published: BMC 2021-11-01
Series:BMC Neuroscience
Subjects:
Lipopolysaccharides (LPS)
Metformin
NF-κB
Neuronal injury
Cognitive impairments
Online Access:https://doi.org/10.1186/s12868-021-00678-5

Internet

https://doi.org/10.1186/s12868-021-00678-5

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