Pre-clinical safety and therapeutic efficacy of a plant-based alkaloid in a human colon cancer xenograft model

Pre-clinical safety and therapeutic efficacy of a plant-based alkaloid in a human colon cancer xenograft model

Abstract A high-throughput drug screen revealed that veratridine (VTD), a natural plant alkaloid, induces expression of the anti-cancer protein UBXN2A in colon cancer cells. UBXN2A suppresses mortalin, a heat shock protein, with dominant roles in cancer development including epithelial–mesenchymal t...

Full description

Bibliographic Details
Main Authors: Jessica L. Freeling, Jamie L. Scholl, Morgan Eikanger, Cole Knoblich, Rashaun A. Potts, David J. Anderson, Joseph E. Rower, Mohammad Hadi Farjoo, Haotian Zhao, Angela Pillatzki, Khosrow Rezvani
Format: Article
Language:English
Published: Nature Publishing Group 2022-03-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-00936-3

Internet

https://doi.org/10.1038/s41420-022-00936-3

Similar Items