Nuciferine induces autophagy to relieve vascular cell adhesion molecule 1 activation via repressing the Akt/mTOR/AP1 signal pathway in the vascular endothelium

Nuciferine induces autophagy to relieve vascular cell adhesion molecule 1 activation via repressing the Akt/mTOR/AP1 signal pathway in the vascular endothelium

Pro-inflammatory factor-associated vascular cell adhesion molecule 1 (VCAM1) activation initiates cardiovascular events. This study aimed to explore the protective role of nuciferine on TNFα-induced VCAM1 activation. Nuciferine was administrated to both high-fat diet (HFD)-fed mice and the TNFα-expo...

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Bibliographic Details
Main Authors: Haibin Wei, Yujie Yin, Wenwen Yang, Jinyan Zhu, Lin Chen, Rui Guo, Zhen Yang, Songtao Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Pharmacology
Subjects:
nuciferine
VCAM1
autophagy
AP1
AKT/mTOR
vascular endothelium
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1264324/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1264324/full

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