Increased Dose to Organs in Urinary Tract Associates With Measures of Genitourinary Toxicity in Pooled Voxel-Based Analysis of 3 Randomized Phase III Trials

Increased Dose to Organs in Urinary Tract Associates With Measures of Genitourinary Toxicity in Pooled Voxel-Based Analysis of 3 Randomized Phase III Trials

Purpose: Dose information from organ sub-regions has been shown to be more predictive of genitourinary toxicity than whole organ dose volume histogram information. This study aimed to identify anatomically-localized regions where 3D dose is associated with genitourinary toxicities in healthy tissues...

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Bibliographic Details
Main Authors: Marco Marcello, James W. Denham, Angel Kennedy, Annette Haworth, Allison Steigler, Peter B. Greer, Lois C. Holloway, Jason A. Dowling, Michael G. Jameson, Dale Roach, David J. Joseph, Sarah L. Gulliford, David P. Dearnaley, Matthew R. Sydes, Emma Hall, Martin A. Ebert
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
external beam radiotherapy
prostate cancer
urinary toxicity
voxel-based analysis
dose-toxicity relationships
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01174/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01174/full

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