The Integrity of the Blood–Brain Barrier as a Critical Factor for Regulating Glutamate Levels in Traumatic Brain Injury

The Integrity of the Blood–Brain Barrier as a Critical Factor for Regulating Glutamate Levels in Traumatic Brain Injury

A healthy blood–brain barrier (BBB) shields the brain from high concentrations of blood glutamate, which can cause neurotoxicity and neurodegeneration. It is believed that traumatic brain injury (TBI) causes long-term BBB disruption, subsequently increasing brain glutamate in the blood, in addition...

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Bibliographic Details
Main Authors: Matthew Boyko, Benjamin F. Gruenbaum, Dmitry Frank, Dmitry Natanel, Shahar Negev, Abed N. Azab, Guy Barsky, Boris Knyazer, Ora Kofman, Alexander Zlotnik
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
blood–brain barrier (BBB)
glutamate
neurotoxicity
rats
traumatic brain injury (TBI)
Online Access:https://www.mdpi.com/1422-0067/24/6/5897

Internet

https://www.mdpi.com/1422-0067/24/6/5897

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