Hypoxia-induced HIF-1α/lncRNA-PMAN inhibits ferroptosis by promoting the cytoplasmic translocation of ELAVL1 in peritoneal dissemination from gastric cancer

Hypoxia-induced HIF-1α/lncRNA-PMAN inhibits ferroptosis by promoting the cytoplasmic translocation of ELAVL1 in peritoneal dissemination from gastric cancer

Peritoneal metastasis (PM) is the main site of gastric cancer (GC) distant metastasis and indicates an extremely poor prognosis and survival. Hypoxia is a common feature of peritoneal metastases and up-regulation of hypoxia inducible factor 1 alpha (HIF-1α) may be a potential driver in the occurrenc...

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Bibliographic Details
Main Authors: Zaihuan Lin, Jialin Song, Yuke Gao, Sihao Huang, Rongzhang Dou, Panyi Zhong, Guoquan Huang, Lei Han, Jinsen Zheng, Xinyao Zhang, Shuyi Wang, Bin Xiong
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Redox Biology
Subjects:
Hypoxia
Ferroptosis
ROS
HIF-1α
lncRNA
ELAVL1 translocation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722000842

Internet

http://www.sciencedirect.com/science/article/pii/S2213231722000842

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