Indole-2-Carboxamide as an Effective Scaffold for the Design of New TRPV1 Agonists

Indole-2-Carboxamide as an Effective Scaffold for the Design of New TRPV1 Agonists

Due to its central role in pain, inflammation, and related disorders, the Transient Receptor Potential (TPR) Vanilloid Type-1 (TRPV1) ion channel represents an attractive target for the development of novel antinociceptive and anti-inflammatory agents. Capsaicin, the natural component of chili peppe...

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Bibliographic Details
Main Authors: Samuele Maramai, Claudia Mugnaini, Marco Paolino, Aniello Schiano Moriello, Luciano De Petrocellis, Federico Corelli, Francesca Aiello, Antonella Brizzi
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Molecules
Subjects:
TRPV1 agonist
indole-2-carboxamides
pain
capsaicin
Online Access:https://www.mdpi.com/1420-3049/30/3/721

Internet

https://www.mdpi.com/1420-3049/30/3/721

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