Disease-causing mutated ATLASTIN 3 is excluded from distal axons and reduces axonal autophagy

Disease-causing mutated ATLASTIN 3 is excluded from distal axons and reduces axonal autophagy

Mutations in the ER-network forming GTPase atlastin3 (ATL3) can cause axon degeneration of sensory neurons by not fully understood mechanisms. We here show that the hereditary sensory and autonomous neuropathy (HSAN)-causing ATL3 Y192C or P338R are excluded from distal axons by a barrier at the axon...

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Bibliographic Details
Main Authors: Laura Behrendt, Christian Hoischen, Christoph Kaether
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neurobiology of Disease
Subjects:
Atlastin
Axonopathy
Hereditary sensory neuropathy
Endoplasmic reticulum
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121001492

Internet

http://www.sciencedirect.com/science/article/pii/S0969996121001492

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