Defining Melanoma Immune Biomarkers—Desert, Excluded, and Inflamed Subtypes—Using a Gene Expression Classifier Reflecting Intratumoral Immune Response and Stromal Patterns

Defining Melanoma Immune Biomarkers—Desert, Excluded, and Inflamed Subtypes—Using a Gene Expression Classifier Reflecting Intratumoral Immune Response and Stromal Patterns

The spatial distribution of tumor infiltrating lymphocytes (TILs) defines several histologically and clinically distinct immune subtypes—desert (no TILs), excluded (TILs in stroma), and inflamed (TILs in tumor parenchyma). To date, robust classification of immune subtypes still requires deeper exper...

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Bibliographic Details
Main Authors: Agata Mlynska, Jolita Gibavičienė, Otilija Kutanovaitė, Linas Senkus, Julija Mažeikaitė, Ieva Kerševičiūtė, Vygantė Maskoliūnaitė, Neda Rupeikaitė, Rasa Sabaliauskaitė, Justina Gaiževska, Karolina Suveizdė, Jan Aleksander Kraśko, Neringa Dobrovolskienė, Emilija Paberalė, Eglė Žymantaitė, Vita Pašukonienė
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Biomolecules
Subjects:
melanoma
tumor-infiltrating lymphocytes
biomarkers
immune subtypes
desert
excluded
Online Access:https://www.mdpi.com/2218-273X/14/2/171

Internet

https://www.mdpi.com/2218-273X/14/2/171

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