Hypoxia Drives Material‐Induced Heterotopic Bone Formation by Enhancing Osteoclastogenesis via M2/Lipid‐Loaded Macrophage Axis

Hypoxia Drives Material‐Induced Heterotopic Bone Formation by Enhancing Osteoclastogenesis via M2/Lipid‐Loaded Macrophage Axis

Abstract Heterotopic ossification (HO) is a double‐edged sword. Pathological HO presents as an undesired clinical complication, whereas controlled heterotopic bone formation by synthetic osteoinductive materials shows promising therapeutic potentials for bone regeneration. However, the mechanism of...

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Bibliographic Details
Main Authors: Dan Li, Yucan Jiang, Ping He, Yeming Li, Yan Wu, Wei Lei, Nanxin Liu, Joost D. deBruijn, Hua Zhang, Hongmei Zhang, Ping Ji, Huipin Yuan, Mingzheng Li
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Advanced Science
Subjects:
heterotopic ossification
hypoxia
macrophage polarization
osteoclast
osteoinductive materials
Online Access:https://doi.org/10.1002/advs.202207224

Internet

https://doi.org/10.1002/advs.202207224

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