Targeting EphA2 and DDR signaling can overcome the BRAF and MEK inhibitors acquired resistance in melanoma cell lines

Targeting EphA2 and DDR signaling can overcome the BRAF and MEK inhibitors acquired resistance in melanoma cell lines

Abstract The BRAF and MEK inhibitors combined strategies have dramatically changed the outcome of BRAF-mutated metastatic melanoma patients. However, despite the initial promising results, the onset of primary or acquired resistance occurs in nearly half of the patients at about one year from the di...

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Bibliographic Details
Main Authors: Valentina Belli, Stefania Napolitano, Vincenzo De Falco, Gabriella Suarato, Alessandra Perrone, Luigi Pio Guerrera, Giulia Martini, Carminia Maria Della Corte, Erika Martinelli, Floriana Morgillo, Mimmo Turano, Maria Furia, Giuseppe Argenziano, Davide Ciardiello, Fortunato Ciardiello, Teresa Troiani
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Translational Medicine Communications
Subjects:
Metastatic melanoma
Drug resistance
BRAF and MEK inhibitors
EMT transition
EPH signaling
DDR signaling, multikinase inhibitors, ALW‑II‑41‑27 inhibitor
Online Access:https://doi.org/10.1186/s41231-022-00133-5

Internet

https://doi.org/10.1186/s41231-022-00133-5

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