Evaluation of MLPA as a comprehensive molecular cytogenetic tool to detect cytogenetic markers of chronic lymphocytic leukemia in Egyptian patients

Evaluation of MLPA as a comprehensive molecular cytogenetic tool to detect cytogenetic markers of chronic lymphocytic leukemia in Egyptian patients

Abstract Background Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia. This disease is genetically heterogeneous, and approximately 85% of patients with CLL harbor chromosomal aberrations that are considered effective prognostic biomarkers. The most frequent aberrations in...

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Bibliographic Details
Main Authors: Ola M. Eid, Rania M. A. Abdel Kader, Lamiaa A. Fathalla, Amany H. Abdelrahman, Ahmed Rabea, Rana Mahrous, Maha M. Eid
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Journal of Genetic Engineering and Biotechnology
Subjects:
Chronic lymphocytic leukemia (CLL)
Chromosomal aberrations
Multiplex ligation-dependent probe amplification (MLPA)
Fluorescence in situ hybridization (FISH)
Online Access:https://doi.org/10.1186/s43141-021-00198-z

Internet

https://doi.org/10.1186/s43141-021-00198-z

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