Mini-HA Is Superior to Full Length Hemagglutinin Immunization in Inducing Stem-Specific Antibodies and Protection Against Group 1 Influenza Virus Challenges in Mice

Mini-HA Is Superior to Full Length Hemagglutinin Immunization in Inducing Stem-Specific Antibodies and Protection Against Group 1 Influenza Virus Challenges in Mice

Seasonal influenza vaccines are updated almost annually to match the antigenic drift in influenza hemagglutinin (HA) surface glycoprotein. A new HA stem-based antigen, the so-called “mini-HA,” was recently shown to induce cross-protective antibodies. However, cross-reactive antibodies targeting the...

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Bibliographic Details
Main Authors: Joan E. M. van der Lubbe, Johan W. A. Verspuij, Jeroen Huizingh, Sonja P. R. Schmit-Tillemans, Jeroen T. B. M. Tolboom, Liesbeth E. H. A. Dekking, Ted Kwaks, Börries Brandenburg, Wim Meijberg, Roland C. Zahn, Ramon Roozendaal, Harmjan Kuipers
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
universal influenza vaccine
hemagglutinin stem immunogen
influenza
mouse influenza challenge models
antibodies
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02350/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02350/full

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