Inflammatory Cytokines That Enhance Antigen Responsiveness of Naïve CD8<sup>+</sup> T Lymphocytes Modulate Chromatin Accessibility of Genes Impacted by Antigen Stimulation

Inflammatory Cytokines That Enhance Antigen Responsiveness of Naïve CD8<sup>+</sup> T Lymphocytes Modulate Chromatin Accessibility of Genes Impacted by Antigen Stimulation

Naïve CD8<sup>+</sup> T lymphocytes exposed to certain inflammatory cytokines undergo proliferation and display increased sensitivity to antigens. Such ‘cytokine priming’ can promote the activation of potentially autoreactive and antitumor CD8<sup>+</sup> T cells by weak tiss...

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Bibliographic Details
Main Authors: Akouavi Julite Irmine Quenum, Madanraj Appiya Santharam, Sheela Ramanathan, Subburaj Ilangumaran
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
inflammatory cytokines
IL-15
IL-21
naïve CD8<sup>+</sup> T cells
TCR
cytokine priming
Online Access:https://www.mdpi.com/1422-0067/23/22/14122

Internet

https://www.mdpi.com/1422-0067/23/22/14122

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