Efficiency of antioxidant Avenanthramide-C on high-dose methotrexate-induced ototoxicity in mice.

Methotrexate (MTX) has been used in treating various types of cancers but can also cause damage to normal organs and cell types. Folinic acid (FA) is a well-known MTX antidote that protects against toxicity caused by the drug and has been used for decades. Since hearing loss caused by MTX treatment...

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Bibliographic Details
Main Authors: Alphonse Umugire, Youngmi Choi, Sungsu Lee, Hyong-Ho Cho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0266108