GWAS reveals genetic basis of a predisposition to severe COVID-19 through in silico modeling of the FYCO1 protein

GWAS reveals genetic basis of a predisposition to severe COVID-19 through in silico modeling of the FYCO1 protein

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, is heavily reliant on its natural ability to “hack” the host’s genetic and biological pathways. The genetic susceptibility of the host is a key factor underlying the severity of the disease. Polygenic risk...

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Bibliographic Details
Main Authors: Mariya S. Gusakova, Mikhail V. Ivanov, Daria A. Kashtanova, Anastasiia N. Taraskina, Veronika V. Erema, Valeriya M. Mikova, Robert I. Loshkarev, Olga A. Ignatyeva, Aleksandra I. Akinshina, Sergey I. Mitrofanov, Ekaterina A. Snigir, Vladimir S. Yudin, Valentin V. Makarov, Anton A. Keskinov, Sergey M. Yudin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Medicine
Subjects:
genome-wide association study
COVID-19
protein folding
FYCO1
polygenic risk score
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1178939/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1178939/full

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