MiR-210-5p promotes the differentiation of human induced pluripotent stem cells into dopaminergic neural precursors by targeting SMAD4 and SUFU and treats parkinsonian rats

MiR-210-5p promotes the differentiation of human induced pluripotent stem cells into dopaminergic neural precursors by targeting SMAD4 and SUFU and treats parkinsonian rats

The differentiation of human induced pluripotent stem cells (hiPSCs) into functional dopaminergic neural precursors is the basis of cell therapy for Parkinson's disease (PD). However, the use of small molecule inhibitors/activators in the differentiation of hiPSCs in vitro leads to cell death a...

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Bibliographic Details
Main Authors: Ying Lyu, Zhongqiang Su, Guosheng Ye, Xiulan He, Yue Liu, Qiao Yin, Fanbing Xie, Liping Xu, Yuncai Chen, Dahong Long
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Experimental Gerontology
Subjects:
Parkinson's disease
Human induced pluripotent stem cell
Differentiation
Dopaminergic neural precursor
miR-210-5p
Online Access:http://www.sciencedirect.com/science/article/pii/S053155652300164X

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http://www.sciencedirect.com/science/article/pii/S053155652300164X

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