Chemical screen for epigenetic barriers to single allele activation of Oct4

Chemical screen for epigenetic barriers to single allele activation of Oct4

Here we utilized the chromatin in vivo assay (CiA) mouse platform to directly examine the epigenetic barriers impeding the activation of the CiA:Oct4 allele in mouse embryonic fibroblasts (MEF)s when stimulated with a transcription factor. The CiA:Oct4 allele contains an engineered EGFP reporter rep...

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Bibliographic Details
Main Authors: Kathryn M. Headley, Katarzyna M. Kedziora, Aidin Alejo, Elianna Zhi-Xiang Lai, Jeremy E. Purvis, Nathaniel A. Hathaway
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S187350611930100X

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http://www.sciencedirect.com/science/article/pii/S187350611930100X

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