Angiotensin I-converting enzyme Gln1069Arg mutation impairs trafficking to the cell surface resulting in selective denaturation of the C-domain.

Angiotensin I-converting enzyme Gln1069Arg mutation impairs trafficking to the cell surface resulting in selective denaturation of the C-domain.

BACKGROUND: Angiotensin-converting enzyme (ACE; Kininase II; CD143) hydrolyzes small peptides such as angiotensin I, bradykinin, substance P, LH-RH and several others and thus plays a key role in blood pressure regulation and vascular remodeling. Complete absence of ACE in humans leads to renal tubu...

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Bibliographic Details
Main Authors: Sergei M Danilov, Sergey Kalinin, Zhenlong Chen, Elena I Vinokour, Andrew B Nesterovitch, David E Schwartz, Olivier Gribouval, Marie-Claire Gubler, Richard D Minshall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2862704?pdf=render

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http://europepmc.org/articles/PMC2862704?pdf=render

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