αβ-T cell receptor transduction gives superior mitochondrial function to γδ-T cells with promising persistence

αβ-T cell receptor transduction gives superior mitochondrial function to γδ-T cells with promising persistence

Summary: Adoptive cell therapy using allogeneic γδ-T cells is a promising option for off-the-shelf T cell products with a low risk of graft-versus-host disease (GVHD). Long-term persistence may boost the clinical development of γδ-T cell products. In this study, we found that genetically modified Vγ...

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Bibliographic Details
Main Authors: Mikiya Ishihara, Hiroshi Miwa, Hiroshi Fujiwara, Yasushi Akahori, Takuma Kato, Yoshimasa Tanaka, Isao Tawara, Hiroshi Shiku
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Cellular therapy
Molecular biology
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223018795

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223018795

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