Process intensification for lentiviral vector manufacturing using tangential flow depth filtration

Process intensification for lentiviral vector manufacturing using tangential flow depth filtration

For gene therapies to become more accessible and affordable treatment options, process intensification is one possible strategy to increase the number of doses generated per batch of viral vector. Process intensification for lentiviral vector manufacturing can be achieved by enabling perfusion in th...

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Bibliographic Details
Main Authors: Robert M. Tona, Reeti Shah, Kimberly Middaugh, Justin Steve, João Marques, Blair R. Roszell, Cindy Jung
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
process intensification
perfusion
tangential flow depth filtration
bioreactor
lentiviral vectors
continuous manufacturing
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012300027X

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http://www.sciencedirect.com/science/article/pii/S232905012300027X

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