A Progress Report and Roadmap for Microphysiological Systems and Organ-On-A-Chip Technologies to Be More Predictive Models in Human (Knee) Osteoarthritis
Osteoarthritis (OA), a chronic debilitating joint disease affecting hundreds of million people globally, is associated with significant pain and socioeconomic costs. Current treatment modalities are palliative and unable to stop the progressive degeneration of articular cartilage in OA. Scientific a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.886360/full |
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| author | Mario Rothbauer Mario Rothbauer Mario Rothbauer Eva I. Reihs Eva I. Reihs Eva I. Reihs Anita Fischer Reinhard Windhager Reinhard Windhager Florien Jenner Stefan Toegel Stefan Toegel |
| author_facet | Mario Rothbauer Mario Rothbauer Mario Rothbauer Eva I. Reihs Eva I. Reihs Eva I. Reihs Anita Fischer Reinhard Windhager Reinhard Windhager Florien Jenner Stefan Toegel Stefan Toegel |
| author_sort | Mario Rothbauer |
| collection | DOAJ |
| description | Osteoarthritis (OA), a chronic debilitating joint disease affecting hundreds of million people globally, is associated with significant pain and socioeconomic costs. Current treatment modalities are palliative and unable to stop the progressive degeneration of articular cartilage in OA. Scientific attention has shifted from the historical view of OA as a wear-and-tear cartilage disorder to its recognition as a whole-joint disease, highlighting the contribution of other knee joint tissues in OA pathogenesis. Despite much progress in the field of microfluidic systems/organs-on-a-chip in other research fields, current in vitro models in use do not yet accurately reflect the complexity of the OA pathophenotype. In this review, we provide: 1) a detailed overview of the most significant recent developments in the field of microsystems approaches for OA modeling, and 2) an OA-pathophysiology-based bioengineering roadmap for the requirements of the next generation of more predictive and authentic microscale systems fit for the purpose of not only disease modeling but also of drug screening to potentially allow OA animal model reduction and replacement in the near future. |
| first_indexed | 2024-12-12T07:50:14Z |
| format | Article |
| id | doaj.art-3238d8286a8a40ffb4563fdf083d4f6d |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-12T07:50:14Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-3238d8286a8a40ffb4563fdf083d4f6d2022-12-22T00:32:27ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-06-011010.3389/fbioe.2022.886360886360A Progress Report and Roadmap for Microphysiological Systems and Organ-On-A-Chip Technologies to Be More Predictive Models in Human (Knee) OsteoarthritisMario Rothbauer0Mario Rothbauer1Mario Rothbauer2Eva I. Reihs3Eva I. Reihs4Eva I. Reihs5Anita Fischer6Reinhard Windhager7Reinhard Windhager8Florien Jenner9Stefan Toegel10Stefan Toegel11Karl Chiari Lab for Orthopeadic Biology, Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Vienna, AustriaFaculty of Technical Chemistry, Vienna University of Technology, Vienna, AustriaLudwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, AustriaKarl Chiari Lab for Orthopeadic Biology, Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Vienna, AustriaFaculty of Technical Chemistry, Vienna University of Technology, Vienna, AustriaLudwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, AustriaKarl Chiari Lab for Orthopeadic Biology, Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Vienna, AustriaKarl Chiari Lab for Orthopeadic Biology, Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Vienna, AustriaDepartment of Orthopedics and Trauma Surgery, Medical University of Vienna, Vienna, AustriaVeterinary Tissue Engineering and Regenerative Medicine Vienna (VETERM), Equine Surgery Unit, University of Veterinary Medicine Vienna, Vienna, AustriaKarl Chiari Lab for Orthopeadic Biology, Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Vienna, AustriaLudwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, AustriaOsteoarthritis (OA), a chronic debilitating joint disease affecting hundreds of million people globally, is associated with significant pain and socioeconomic costs. Current treatment modalities are palliative and unable to stop the progressive degeneration of articular cartilage in OA. Scientific attention has shifted from the historical view of OA as a wear-and-tear cartilage disorder to its recognition as a whole-joint disease, highlighting the contribution of other knee joint tissues in OA pathogenesis. Despite much progress in the field of microfluidic systems/organs-on-a-chip in other research fields, current in vitro models in use do not yet accurately reflect the complexity of the OA pathophenotype. In this review, we provide: 1) a detailed overview of the most significant recent developments in the field of microsystems approaches for OA modeling, and 2) an OA-pathophysiology-based bioengineering roadmap for the requirements of the next generation of more predictive and authentic microscale systems fit for the purpose of not only disease modeling but also of drug screening to potentially allow OA animal model reduction and replacement in the near future.https://www.frontiersin.org/articles/10.3389/fbioe.2022.886360/fullosteoarthritisorgans-on-a-chipmicrophysiological system (MPS)roadmapdisease modelingalternative methods to animal testing |
| spellingShingle | Mario Rothbauer Mario Rothbauer Mario Rothbauer Eva I. Reihs Eva I. Reihs Eva I. Reihs Anita Fischer Reinhard Windhager Reinhard Windhager Florien Jenner Stefan Toegel Stefan Toegel A Progress Report and Roadmap for Microphysiological Systems and Organ-On-A-Chip Technologies to Be More Predictive Models in Human (Knee) Osteoarthritis Frontiers in Bioengineering and Biotechnology osteoarthritis organs-on-a-chip microphysiological system (MPS) roadmap disease modeling alternative methods to animal testing |
| title | A Progress Report and Roadmap for Microphysiological Systems and Organ-On-A-Chip Technologies to Be More Predictive Models in Human (Knee) Osteoarthritis |
| title_full | A Progress Report and Roadmap for Microphysiological Systems and Organ-On-A-Chip Technologies to Be More Predictive Models in Human (Knee) Osteoarthritis |
| title_fullStr | A Progress Report and Roadmap for Microphysiological Systems and Organ-On-A-Chip Technologies to Be More Predictive Models in Human (Knee) Osteoarthritis |
| title_full_unstemmed | A Progress Report and Roadmap for Microphysiological Systems and Organ-On-A-Chip Technologies to Be More Predictive Models in Human (Knee) Osteoarthritis |
| title_short | A Progress Report and Roadmap for Microphysiological Systems and Organ-On-A-Chip Technologies to Be More Predictive Models in Human (Knee) Osteoarthritis |
| title_sort | progress report and roadmap for microphysiological systems and organ on a chip technologies to be more predictive models in human knee osteoarthritis |
| topic | osteoarthritis organs-on-a-chip microphysiological system (MPS) roadmap disease modeling alternative methods to animal testing |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.886360/full |
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