Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy

Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy

Loss of innervation is a key driver of age associated muscle atrophy and weakness (sarcopenia). Our laboratory has previously shown that denervation induced atrophy is associated with the generation of mitochondrial hydroperoxides and lipid mediators produced downstream of cPLA2 and 12/15 lipoxygena...

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Bibliographic Details
Main Authors: Jacob L. Brown, Fredrick F. Peelor, III, Constantin Georgescu, Jonathan D. Wren, Michael Kinter, Victoria J. Tyrrell, Valerie B. O'Donnell, Benjamin F. Miller, Holly Van Remmen
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Redox Biology
Subjects:
Skeletal
Mitochondria
ROS
Neuromuscular junction
Lipoxygenase
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722002907

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http://www.sciencedirect.com/science/article/pii/S2213231722002907

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