Flexible pri-miRNA structures enable tunable production of 5’ isomiRs

Flexible pri-miRNA structures enable tunable production of 5’ isomiRs

The Drosha cleavage of a pri-miRNA defines mature microRNA sequence. Drosha cleavage at alternative positions generates 5’ isoforms (isomiRs) which have distinctive functions. To understand how pri-miRNA structures influence Drosha cleavage, we performed a systematic analysis of the maturation of en...

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Bibliographic Details
Main Authors: Xavier Bofill-De Ros, Zhenyi Hong, Ben Birkenfeld, Sarangelica Alamo-Ortiz, Acong Yang, Lisheng Dai, Shuo Gu
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:RNA Biology
Subjects:
drosha
dicer
cleavage fidelity
alternative cleavage
5’ isomirs
pri-mirna
rna structure
rna-binding proteins
Online Access:http://dx.doi.org/10.1080/15476286.2022.2025680

Internet

http://dx.doi.org/10.1080/15476286.2022.2025680

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