Spatial interplay of tissue hypoxia and T-cell regulation in ductal carcinoma in situ

Spatial interplay of tissue hypoxia and T-cell regulation in ductal carcinoma in situ

Abstract Hypoxia promotes aggressive tumor phenotypes and mediates the recruitment of suppressive T cells in invasive breast carcinomas. We investigated the role of hypoxia in relation to T-cell regulation in ductal carcinoma in situ (DCIS). We designed a deep learning system tailored for the tissue...

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Bibliographic Details
Main Authors: Faranak Sobhani, Sathya Muralidhar, Azam Hamidinekoo, Allison H. Hall, Lorraine M. King, Jeffrey R. Marks, Carlo Maley, Hugo M. Horlings, E. Shelley Hwang, Yinyin Yuan
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-022-00419-9

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https://doi.org/10.1038/s41523-022-00419-9

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