Resolution of Racemic Aryloxy-Propan-2-yl Acetates via Lipase-Catalyzed Hydrolysis: Preparation of Enantiomerically Pure/Enantioenriched Mexiletine Intermediates and Analogs

Resolution of Racemic Aryloxy-Propan-2-yl Acetates via Lipase-Catalyzed Hydrolysis: Preparation of Enantiomerically Pure/Enantioenriched Mexiletine Intermediates and Analogs

The lipase kinetic resolution (KR) of aryloxy-propan-2-yl acetates, via hydrolysis, produced enantiomerically pure/enantioenriched mexiletine intermediates and analogs. Racemic acetates <i>rac</i>-1-(2,6-dimethylphenoxy)propan-2-yl acetate (<i>rac</i>-<b>5a</b>),...

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Bibliographic Details
Main Authors: Ana Caroline Lustosa de Melo Carvalho, Bruna Rocha de Oliveira, Gledson Vieira Lima, Jonatas Martins Negreiro, Maria Conceição Ferreira Oliveira, Telma Leda Gomes de Lemos, Marcos Reinaldo da Silva, Thiago de Sousa Fonseca, Rayanne Mendes Bezerra, Jose Cleiton Sousa dos Santos, Luciana Rocha Barros Gonçalves, Nathalia Saraiva Rios, Geancarlo Zanatta, Marcos Carlos de Mattos
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Catalysts
Subjects:
enzymatic kinetic resolution
lipases
mexiletine analog intermediates
biocatalysis
molecular docking
Online Access:https://www.mdpi.com/2073-4344/12/12/1566

Internet

https://www.mdpi.com/2073-4344/12/12/1566

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