Intracellular pH dynamics regulates intestinal stem cell lineage specification

Abstract Intracellular pH dynamics is increasingly recognized to regulate myriad cell behaviors. We report a finding that intracellular pH dynamics also regulates adult stem cell lineage specification. We identify an intracellular pH gradient in mouse small intestinal crypts, lowest in crypt stem ce...

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Бібліографічні деталі
Автори: Yi Liu, Efren Reyes, David Castillo-Azofeifa, Ophir D. Klein, Todd Nystul, Diane L. Barber
Формат: Стаття
Мова:English
Опубліковано: Nature Portfolio 2023-06-01
Серія:Nature Communications
Онлайн доступ:https://doi.org/10.1038/s41467-023-39312-9