Suppression of CPSF6 Enhances Apoptosis Through Alternative Polyadenylation-Mediated Shortening of the VHL 3′UTR in Gastric Cancer Cells

Suppression of CPSF6 Enhances Apoptosis Through Alternative Polyadenylation-Mediated Shortening of the VHL 3′UTR in Gastric Cancer Cells

Alternative polyadenylation (APA) is an important RNA post-transcriptional process, which can generate diverse mRNA isoforms. Increasing evidence shows that APA is involved in cell self-renewal, development, immunity, and cancer. CPSF6 is one of the core proteins of CFIm complex and can modulate the...

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Bibliographic Details
Main Authors: Xinglong Shi, Keshuo Ding, Qiang Zhao, Pengxiao Li, Yani Kang, Sheng Tan, Jielin Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Genetics
Subjects:
alternative polyadenylation
gastric cancer
apoptosis
CPSF6
VHL
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.707644/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.707644/full

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