Neutrophil extracellular traps are involved in enhanced contact hypersensitivity response in IL-36 receptor antagonist-deficient mice

Neutrophil extracellular traps are involved in enhanced contact hypersensitivity response in IL-36 receptor antagonist-deficient mice

Abstract Loss-of-function homozygous or compound heterozygous mutations in IL36RN, which encodes interleukin-36 receptor antagonist (IL-36Ra), have been implicated in the pathogenesis of skin disorders. We previously reported that Il36rn −/− mice exhibit an enhanced contact hypersensitivity (CHS) re...

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Bibliographic Details
Main Authors: Yurie Hasegawa, Yohei Iwata, Hidehiko Fukushima, Yoshihito Tanaka, Soichiro Watanabe, Kenta Saito, Hiroyuki Ito, Mizuki Sugiura, Masashi Akiyama, Kazumitsu Sugiura
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-16449-z

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https://doi.org/10.1038/s41598-022-16449-z

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