Motor unit number index (MUNIX) in the D50 disease progression model reflects disease accumulation independently of disease aggressiveness in ALS

Motor unit number index (MUNIX) in the D50 disease progression model reflects disease accumulation independently of disease aggressiveness in ALS

Abstract The neurophysiological technique motor unit number index (MUNIX) is increasingly used in clinical trials to measure loss of motor units. However, the heterogeneous disease course in amyotrophic lateral sclerosis (ALS) obfuscates robust correlations between clinical status and electrophysiol...

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Bibliographic Details
Main Authors: Theresa Ebersbach, Annekathrin Roediger, Robert Steinbach, Martin Appelfeller, Anke Tuemmler, Beatrice Stubendorff, Simon Schuster, Meret Herdick, Hubertus Axer, Otto W. Witte, Julian Grosskreutz
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-19911-0

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https://doi.org/10.1038/s41598-022-19911-0

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