Entecavir as a P2X7R antagonist ameliorates platelet activation and thrombus formation

Entecavir as a P2X7R antagonist ameliorates platelet activation and thrombus formation

Platelet activation is the primary cause of thrombosis. The P2X7 receptor (P2X7R) is a therapeutic target of thrombosis. However, it is still unknown whether P2X7R activation affects platelet thrombus. Our molecular docking results showed that entecavir as a P2X7R antagonist interacted perfectly wit...

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Bibliographic Details
Main Authors: Yue Ming, Guang Xin, Beihong Ji, Chengji Ji, Zeliang Wei, Boli Zhang, Junhua Zhang, Kui Yu, Xiaoyu Zhang, Shiyi Li, Youping Li, Zhihua Xing, Hai Niu, Wen Huang
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Journal of Pharmacological Sciences
Subjects:
Entecavir
Platelet
P2X7 receptor
Mitochondria
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300669

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http://www.sciencedirect.com/science/article/pii/S1347861320300669

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