Precision sirolimus dosing in children: The potential for model-informed dosing and novel drug monitoring

Precision sirolimus dosing in children: The potential for model-informed dosing and novel drug monitoring

The mTOR inhibitor sirolimus is prescribed to treat children with varying diseases, ranging from vascular anomalies to sporadic lymphangioleiomyomatosis to transplantation (solid organ or hematopoietic cell). Precision dosing of sirolimus using therapeutic drug monitoring (TDM) of sirolimus concentr...

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Bibliographic Details
Main Authors: Guofang Shen, Kao Tang Ying Moua, Kathryn Perkins, Deron Johnson, Arthur Li, Peter Curtin, Wei Gao, Jeannine S. McCune
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
sirolimus (rapamycin)
pediatrics
therapeutic drug monitoring (TDM)
sweat
saliva
dried blood spots (DBS)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1126981/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1126981/full

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