hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma

hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma

Abstract Background Circular RNAs (circRNAs) play important roles in the occurrence and development of cancer and chemoresistance. DNA damage repair contributes to the proliferation of cancer cells and resistance to chemotherapy-induced apoptosis. However, the role of circRNAs in the regulation of D...

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Bibliographic Details
Main Authors: Lei Xu, Xiao Ma, Xiuzhong Zhang, Chong Zhang, Yi Zhang, Shuai Gong, Nai Wu, Peng Zhang, Xinyu Feng, Jiaxuan Guo, Mengmeng Zhao, Zeqiang Ren, Pengbo Zhang
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Molecular Cancer
Subjects:
hsa_circ_0007919
LIG1
DNA damage repair
Pancreatic ductal adenocarcinoma
QKI
Online Access:https://doi.org/10.1186/s12943-023-01887-8

Internet

https://doi.org/10.1186/s12943-023-01887-8

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