Heparan sulphate, its derivatives and analogues share structural characteristics that can be exploited, particularly in inhibiting microbial attachment

Heparan sulphate, its derivatives and analogues share structural characteristics that can be exploited, particularly in inhibiting microbial attachment

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Heparan sulphate (HS) and the related polysaccharide, heparin, exhibit conformational and charge arrangement properties, which provide a degree of redundancy allowing several seemingly distinct sequences to exhibit the same activity. This can also be mimicked by other sulphated polysaccharides, both...

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Bibliographic Details
Main Authors: T.R. Rudd, A. Hughes, J. Holman, V. Solari, E. de Oliveira Ferreira, R.M. Cavalcante Pilotto Domingues, E.A. Yates
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2012-05-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Heparan sulfate
Biosynthesis
Structure-function
Microbial attachment
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000500002

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000500002

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