Cholinergic autoantibodies from primary Sjögren′s syndrome inhibit mucin production via phospholipase C and cyclooxygenase-2 in the rat submandibular gland

Cholinergic autoantibodies from primary Sjögren′s syndrome inhibit mucin production via phospholipase C and cyclooxygenase-2 in the rat submandibular gland

Background: Patients with primary Sjögren′s syndrome (pSS) produce functional IgG against cholinoreceptor of exocrine glands modifying their activity. The aim of the present work was to demonstrate pSS IgG antibodies (pSS IgG) interacting with M 3 muscarinic acetylcholine receptors (mAChR) of rats s...

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Bibliographic Details
Main Authors: Daniela Passafaro, Leonor Sterin-Borda, Silvia Reina, Enri Borda
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2011-01-01
Series:Dental Research Journal
Subjects:
Auto antibodies
InsP
mAChR
Mucin
PGE2
Submandibular gland
Online Access:http://www.drjjournal.net/article.asp?issn=1735-3327;year=2011;volume=8;issue=3;spage=138;epage=145;aulast=Passafaro

Internet

http://www.drjjournal.net/article.asp?issn=1735-3327;year=2011;volume=8;issue=3;spage=138;epage=145;aulast=Passafaro

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