Heritability enrichment in context-specific regulatory networks improves phenotype-relevant tissue identification

Heritability enrichment in context-specific regulatory networks improves phenotype-relevant tissue identification

Systems genetics holds the promise to decipher complex traits by interpreting their associated SNPs through gene regulatory networks derived from comprehensive multi-omics data of cell types, tissues, and organs. Here, we propose SpecVar to integrate paired chromatin accessibility and gene expressio...

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Bibliographic Details
Main Authors: Zhanying Feng, Zhana Duren, Jingxue Xin, Qiuyue Yuan, Yaoxi He, Bing Su, Wing Hung Wong, Yong Wang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-12-01
Series:eLife
Subjects:
heritability enrichment
regulatory network
GWAS
relevant tissues
phenotypic correlation
Online Access:https://elifesciences.org/articles/82535

Internet

https://elifesciences.org/articles/82535

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