Glycine receptor mutants of the mouse: what are possible routes of inhibitory compensation?

Glycine receptor mutants of the mouse: what are possible routes of inhibitory compensation?

Defects in glycinergic inhibition result in a complex neuromotor disorder in humans known as hyperekplexia (OMIM 149400) with similar phenotypes in rodents characterized by an exaggerated startle reflex and hypertonia. Analogous to genetic defects in humans, single point mutations, microdeletions, o...

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Bibliographic Details
Main Authors: Natascha eSchaefer, Nicolas eVogel, Carmen eVillmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
knockout mice
rescue
glycine receptors
hyperekplexia
synaptic inhibition
spontaneous mouse mutants
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00098/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00098/full

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