TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness

TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness

Abstract In mammalian cells, endoplasmic reticulum (ER) passively releases Ca2+ under steady state, but channels involved remain elusive. Here, we report that TMEM41B, an ER-resident membrane protein critical for autophagy, lipid metabolism, and viral infection, functions as an ER Ca2+ release chann...

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Bibliographic Details
Main Authors: Yuying Ma, Yi Wang, Xiaocui Zhao, Gang Jin, Jing Xu, Zhuoyang Li, Na Yin, Zhaobing Gao, Bingqing Xia, Min Peng
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-024-00766-w

Internet

https://doi.org/10.1038/s41421-024-00766-w

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