Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution

Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution

Intermediate transitions between epithelial and mesenchymal states are associated with tumor progression. Here using mass cytometry, Plevritis and colleagues develop a computational framework to resolve and map these trajectories in lung cancer cells and clinical specimens.

Bibliographic Details
Main Authors: Loukia G. Karacosta, Benedict Anchang, Nikolaos Ignatiadis, Samuel C. Kimmey, Jalen A. Benson, Joseph B. Shrager, Robert Tibshirani, Sean C. Bendall, Sylvia K. Plevritis
Format: Article
Language:English
Published: Nature Portfolio 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13441-6

Internet

https://doi.org/10.1038/s41467-019-13441-6

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