Co-Delivery of p53 Restored and E7 Targeted Nucleic Acids by Poly (Beta-Amino Ester) Complex Nanoparticles for the Treatment of HPV Related Cervical Lesions

Co-Delivery of p53 Restored and E7 Targeted Nucleic Acids by Poly (Beta-Amino Ester) Complex Nanoparticles for the Treatment of HPV Related Cervical Lesions

The p53 gene has the highest mutation frequency in tumors, and its inactivation can lead to malignant transformation, such as cell cycle arrest and apoptotic inhibition. Persistent high-risk human papillomavirus (HR-HPV) infection is the leading cause of cervical cancer. P53 was inactivated by HPV o...

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Bibliographic Details
Main Authors: Jinfeng Xiong, Guannan Li, Xinyu Mei, Jiahui Ding, Hui Shen, Da Zhu, Hui Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
p53
human papillomavirus
cervical cancer
poly (beta-amino ester)
nanoparticle
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.826771/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.826771/full

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