Erucic Acid—Both Sides of the Story: A Concise Review on Its Beneficial and Toxic Properties
Erucic acid (EA) is monounsaturated fatty acid (22:1 n-9), synthesized in the seeds of many plants from the <i>Brassicaceae</i> family, with <i>Brassica napus</i>, <i>B. rapa</i>, or <i>B. carinata</i> considered as its richest source. As the compound...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/4/1924 |
| _version_ | 1827756120159027200 |
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| author | Agnieszka Galanty Marta Grudzińska Wojciech Paździora Paweł Paśko |
| author_facet | Agnieszka Galanty Marta Grudzińska Wojciech Paździora Paweł Paśko |
| author_sort | Agnieszka Galanty |
| collection | DOAJ |
| description | Erucic acid (EA) is monounsaturated fatty acid (22:1 n-9), synthesized in the seeds of many plants from the <i>Brassicaceae</i> family, with <i>Brassica napus</i>, <i>B. rapa</i>, or <i>B. carinata</i> considered as its richest source. As the compound has been blamed for the poisoning effect in Toxic Oil Syndrome, and some data indicated its cardiotoxicity to rats, EA has been for decades classified as toxic substance, the use of which should be avoided. However, the cardiac adverse effects of EA have not been confirmed in humans, and the experiments in animal models had many limitations. Thus, the aim of this review was to present the results of the so far published studies on both toxic, and pharmacological properties of EA, trying to answer the question on its future medicinal use. Despite the ambiguous and relatively small data on toxic and beneficial effects of EA it seems that the compound is worth investigating. Further research should be particularly directed at the verification EA toxicity, more in-depth studies on its neuroprotective and cytotoxic properties, but also its use in combination with other drugs, as well as its role as a drug carrier. |
| first_indexed | 2024-03-11T08:20:49Z |
| format | Article |
| id | doaj.art-325433f0ab3d4d8eaa28e0b50e1f53fe |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T08:20:49Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-325433f0ab3d4d8eaa28e0b50e1f53fe2023-11-16T22:25:05ZengMDPI AGMolecules1420-30492023-02-01284192410.3390/molecules28041924Erucic Acid—Both Sides of the Story: A Concise Review on Its Beneficial and Toxic PropertiesAgnieszka Galanty0Marta Grudzińska1Wojciech Paździora2Paweł Paśko3Department of Pharmacognosy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandDepartment of Food Chemistry and Nutrition, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandDepartment of Pharmacognosy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandDepartment of Food Chemistry and Nutrition, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandErucic acid (EA) is monounsaturated fatty acid (22:1 n-9), synthesized in the seeds of many plants from the <i>Brassicaceae</i> family, with <i>Brassica napus</i>, <i>B. rapa</i>, or <i>B. carinata</i> considered as its richest source. As the compound has been blamed for the poisoning effect in Toxic Oil Syndrome, and some data indicated its cardiotoxicity to rats, EA has been for decades classified as toxic substance, the use of which should be avoided. However, the cardiac adverse effects of EA have not been confirmed in humans, and the experiments in animal models had many limitations. Thus, the aim of this review was to present the results of the so far published studies on both toxic, and pharmacological properties of EA, trying to answer the question on its future medicinal use. Despite the ambiguous and relatively small data on toxic and beneficial effects of EA it seems that the compound is worth investigating. Further research should be particularly directed at the verification EA toxicity, more in-depth studies on its neuroprotective and cytotoxic properties, but also its use in combination with other drugs, as well as its role as a drug carrier.https://www.mdpi.com/1420-3049/28/4/1924erucic acidcardiotoxicitycytotoxicneuroprotective |
| spellingShingle | Agnieszka Galanty Marta Grudzińska Wojciech Paździora Paweł Paśko Erucic Acid—Both Sides of the Story: A Concise Review on Its Beneficial and Toxic Properties Molecules erucic acid cardiotoxicity cytotoxic neuroprotective |
| title | Erucic Acid—Both Sides of the Story: A Concise Review on Its Beneficial and Toxic Properties |
| title_full | Erucic Acid—Both Sides of the Story: A Concise Review on Its Beneficial and Toxic Properties |
| title_fullStr | Erucic Acid—Both Sides of the Story: A Concise Review on Its Beneficial and Toxic Properties |
| title_full_unstemmed | Erucic Acid—Both Sides of the Story: A Concise Review on Its Beneficial and Toxic Properties |
| title_short | Erucic Acid—Both Sides of the Story: A Concise Review on Its Beneficial and Toxic Properties |
| title_sort | erucic acid both sides of the story a concise review on its beneficial and toxic properties |
| topic | erucic acid cardiotoxicity cytotoxic neuroprotective |
| url | https://www.mdpi.com/1420-3049/28/4/1924 |
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