Capsaicin-Cyclodextrin Complex Enhances Mepivacaine Targeting and Improves Local Anesthesia in Inflamed Tissues

Capsaicin-Cyclodextrin Complex Enhances Mepivacaine Targeting and Improves Local Anesthesia in Inflamed Tissues

Acidic environments, such as in inflamed tissues, favor the charged form of local anesthetics (LA). Hence, these drugs show less cell permeation and diminished potency. Since the analgesic capsaicin (CAP) triggers opening of the TRPV1 receptor pore, its combination with LAs could result in better up...

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Bibliographic Details
Main Authors: Verônica Muniz Couto, Laura de Oliveira-Nascimento, Luiz Fernando Cabeça, Danilo Costa Geraldes, Juliana Souza Ribeiro Costa, Karin A. Riske, Michelle Franz-Montan, Fabiano Yokaychiya, Margareth K. K. Dias Franco, Eneida de Paula
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
inflammation
mepivacaine
capsaicin
anesthesia
cyclodextrin
Online Access:https://www.mdpi.com/1422-0067/21/16/5741

Internet

https://www.mdpi.com/1422-0067/21/16/5741

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